Opioid dependence and treatment with buprenorphine are topics well suited to teach medical students about the role of practicing physicians in substance abuse treatment, complicated multi-disciplinary treatment issues, complex biological and social basis of addictions, and how new treatments are developed and moved into practice. During Phase I of the grant, we developed a curriculum plan for a suite of modules on these issues as they relate to opioid abuse and dependence with input from a focus group of medical school professionals with experience in substance abuse education. The prototype module entitled “Prevalence, Trends and Impact on Health: Opioid Addiction” was developed and underwent usability and pilot testing with medical students in their 2nd through 4th years of study. Usability testing revealed that students enjoyed the online format, found the module well-organized and easy to navigate, and showed an interest in learning more about Buprenorphine. More in-depth pilot testing assessed the impact of the pilot module on the attitudes, self-efficacy, and intendedbehavior of medical students, as well as changes in knowledge and satisfaction with the module material. A retrospective pre/post design was regarding detecting and treating opioid misuse or abuse significantly increased with the completion of the pilot module.